{ "_id": "6a107ad4acfb0bcc41cadc9b", "Package": "simfam", "Title": "Simulate and Model Family Pedigrees with Structured Founders", "Version": "1.1.16.9000", "Authors@R": "person(given = \"Alejandro\",\nfamily = \"Ochoa\",\nrole = c(\"aut\", \"cre\"),\nemail = \"alejandro.ochoa@duke.edu\",\ncomment = c(ORCID = \"0000-0003-4928-3403\"))", "Description": "The focus is on simulating and modeling families with\nfounders drawn from a structured population (for example, with\ndifferent ancestries or other potentially non-family\nrelatedness), in contrast to traditional pedigree analysis that\ntreats all founders as equally unrelated. Main function\nsimulates a random pedigree for many generations, avoiding\nclose relatives, pairing closest individuals according to a 1D\ngeography and their randomly-drawn sex, and with variable\nchildren sizes to result in a target population size per\ngeneration. Auxiliary functions calculate kinship matrices,\nadmixture matrices, and draw random genotypes across arbitrary\npedigree structures starting from the corresponding founder\nvalues. The code is built around the plink FAM table format\nfor pedigrees. There are functions that simulate independent\nloci and also functions that use an explicit recombination\nmodel to simulate linkage disequilibrium (LD) in the pedigree,\nas well as population analogs resembling the Li-Stephens model.\nDescribed in Yao and Ochoa (2023) .", "License": "GPL (>= 3)", "Encoding": "UTF-8", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.2", "Config/testthat/edition": "3", "VignetteBuilder": "knitr", "URL": "https://github.com/OchoaLab/simfam", "BugReports": "https://github.com/OchoaLab/simfam/issues", "LazyData": "true", "Repository": "https://ochoalab.r-universe.dev", "Date/Publication": "2025-01-08 18:08:26 UTC", "RemoteUrl": "https://github.com/ochoalab/simfam", "RemoteRef": "HEAD", "RemoteSha": "5cd929803cd0ceaf68e3bcfc2f7a3c63a4a33e24", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-05-06 07:57:27 UTC", "User": "root" }, "Author": "Alejandro Ochoa [aut, cre] (ORCID:\n)", "Maintainer": "Alejandro Ochoa ", "MD5sum": 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