Simulate correlated studies for test | Perform meta-analysis | Only estimating study covariance | Under the hood: the correlated Standard Normal product distribution
Package: metalcor 1.0.0
Alejandro Ochoa
metalcor: Meta-Analysis of Correlated Genetic Association Studies
The main function performs meta-analysis of genetic association study summary statistics that may be correlated due to cryptic relatedness or other confounders, generalizing inverse variance weighted methods. The function that estimates the correlation structure is also provided standalone. Another key innovation, the estimation of the correlation parameter from the median product of correlated standard normal variables, is provided, as well as a complete set of functions for their underlying distribution: density, cumulative, quantile, and random deviates. Described in Tu and Ochoa (2025) <doi:10.1101/2025.05.10.653279>.
Authors:
metalcor_1.0.0.tar.gz
metalcor_1.0.0.zip(r-4.7)metalcor_1.0.0.zip(r-4.6)metalcor_1.0.0.zip(r-4.5)
metalcor_1.0.0.tgz(r-4.6-any)metalcor_1.0.0.tgz(r-4.5-any)
metalcor_1.0.0.tar.gz(r-4.7-any)metalcor_1.0.0.tar.gz(r-4.6-any)
metalcor_1.0.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
metalcor/json (API)
| # Install 'metalcor' in R: |
| install.packages('metalcor', repos = c('https://ochoalab.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/ochoalab/metalcor/issues
Last updated from:2c374f19fd. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-x86_64 | OK | 115 | ||
| source / vignettes | OK | 154 | ||
| linux-release-x86_64 | OK | 124 | ||
| macos-release-arm64 | OK | 100 | ||
| macos-oldrel-arm64 | OK | 91 | ||
| windows-devel | OK | 100 | ||
| windows-release | OK | 81 | ||
| windows-oldrel | OK | 83 | ||
| wasm-release | OK | 104 |
Exports:dprodcorestimate_Rmetalcorpprodcorqprodcorrho_from_medianrprodcor
Dependencies:clidplyrgenericsgluelifecyclemagrittrpillarpkgconfigR6rlangtibbletidyselectutf8vctrswithr
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Estimate Covariance Matrix of Study Z-scores | estimate_R |
| Meta-Analysis of Correlated Genetic Association Studies | metalcor |
| The Correlated Standard Normal Product Distribution | dprodcor pprodcor prodcor qprodcor rprodcor |
| Estimated Correlations from Sample Medians of the Correlated Standard Normal Product Distribution | rho_from_median |
